Main Article Content
Objective: To describe epidemiological profile with respect to demographics and seasonal variations in occurrence of Meningitis, Encephalitis and Meningoencephalitis.
Methods: A retrospective review of medical records of meningitis and Encephalitis and Meningo-encephalitis cases from 1st January 2018 to 31st December 2018 from Medicine department at Benghazi Medical Center in Benghazi city, Libya. All patients meeting the case definition were included .Data were collected using questionnaire on demographics including, age, sex, Address, and date of admission and date of discharge, diagnosis.
Results: From January to December 2018, 31 cases were identified, the mean age of all cases was (41.2) years. There were 20 (66.7%) of them males and 10 (33.3%) were females. The proportion of diagnosis of meningitis, encephalitis, and Meningoencephalitis was (22.6%), (25.8%), (51.6%) respectively. Differences were observed in the occurrence of each infection during the year seasons.
Conclusion: Based on data obtained, most infections occured in older age with gender differences in each type of infection. Seasonal variations noticed in all infections. This descriptive study was used as a screening tool to track cases and further larger epidemiological study is needed in order to plan effective preventive and surveillance measures.
Kelly TA, Olorcain P, Moran J, Garvey P, McKeown P, Connell J, et al. Underreporting of viral encephalitis and viral meningitis, Ireland, 2005‐2008. Emerging Infectious Diseases. 2013;19: 1428‐1436.
Roos Karen L, Tyler Kenneth L. Meningitis, encephalitis, brain abscess, and empyema. Harrison's Principles of Internal Medicine (19 Ed.). New York, NY: McGraw-Hill Education; 2015.
Fisman DN. Seasonality of infectious diseases. Annu Rev Public Health. 2007;28:127–43.
Grassly NC, Fraser C. Seasonal infectious disease epidemiology. Proc Biol Sci. 2006;273:2541–50.
Juliette Paireau, Angelica Chen, Helene Broutin, Bryan Grenfell, Nicole E. Basta. Seasonal dynamics of bacterial meningitis: A time-series analysis. Lancet Glob Health. 2016;4(6):e370–e377.
James Sejvar. Neuroepidemiology and the epidemiology of viral infections of the nervous system. Handb Clin Neurol. 2014;123:67–87.
Kuhn K, Campbell-Lendrum D, Haines A, Cox J. Using climate to predict infectious disease epidemics. Geneva: World Health Organ; 2005.
Radhakrishnan K, Maloo JC, Poddar SK, Mousa ME. Central nervous system infections in Benghazi, Libya: Experience from a community-based adult medical neurology set-up. J Trop Med Hyg. 1987;90(3):123-6.
Ayman Yosry, Taha Gad, Waleed Fathalah, Marwa Khairy, Hanan Abd El Hafez, Rabab Fouad. Epidemiological profile of patients suspected with meningitis: A cross-sectional study among 1712 Egyptian patients. International Journal of Microbiology and Immunology Research. 2014;2(4):054-062.
Julia Granerod, Simon Cousens, Nicholas W. S. Davies, Natasha S. Crowcroft, Sara L. Thomas. New estimates of incidence of encephalitis in England. Emerging Infectious Diseases. 2013;19(9).
Amy Y. Wang, Jorge D. Machicado, Nabil T. Khoury, Susan H. Wootton, Lucrecia Salazar, Rodrigo Hasbun. Community-acquired meningitis in older adults: Clinical features, etiology, and prognostic factors. J Am Geriatr Soc. 2014;62(11):2064–2070.
Van De Beek D, De Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004;351:1849–1859.
Lavanya Dharmarajan, Lucrecia Salazar, Rodrigo Hasbun. Gender differences in community-acquired meningitis in adults: Clinical presentations and prognostic factors. J Meningitis. 2016;1(1).
Girgis NI, Sippel JE, Kilpatrick ME, Sanborn WR, Mikhail IA, Cross E, Erian MW, Sultan Y, Farid Z. Meningitis and encephalitis at the Abbassia Fever Hospital, Cairo; 1993.
Guerra-Silveira F, Abad-Franch F. Sex differences in infectious disease epidemiology: Patterns and processes. Plos One. 2013;8.
Yves Traore, Tsidi Agbeko Tameklo, Berthe-Marie Njanpop-Lafourcade, Mathilde Lourd, Seydou Yaro, Dominique Niamba, Aly Drabo, Judith E. Mueller, Jean-Louis Koeck, Bradford D. Gessner. Incidence, seasonality, age distribution, and mortality of pneumococcal meningitis in Burkina Faso and Togo. Clinical Infectious Diseases. 2009; 48(Supplement_2,1):S181–S189.
Azevedo LCP, Toscano CM, Bierrenbach AL. Bacterial meningitis in Brazil: Baseline epidemiologic assessment of the decade prior to the introduction of pneumococcal and meningococcal vaccines. PLoS One. 2013;8:e64524.
Xie Y, Tan Y, Chongsuvivatwong V, Wu X, Bi F, Hadler SC, et al. A population-based acute meningitis and encephalitis syndromes. Surveillance in Guangxi, China, May 2007- June 2012. PLoS ONE. 2015;10(12):e0144366.
DOI: 10.1371/ journal.pone.0144366
Dowell SF, Whitney CG, Wright C, Rose CE, Schuchat A. Seasonal patterns of invasive pneumococcal disease. Emerg Infect Dis. 2003;9:573–79.
Che-Liang Lin, Hsiao-Ling Chang, Chuan-Yao Lin, Kow-Tong Chen. Seasonal patterns of Japanese encephalitis and associated meteorological factors in Taiwan. Int J Environ Res Public Health. 2017;14(11):1317.
[Published online 2017 Oct 29]
Hu Suk Lee, Hung Nguyen-Viet, Mihye Lee, Phuc Pham Duc, Delia Grace. Seasonality of viral encephalitis and associated environmental risk factors in Son La and Thai Binh provinces in Vietnam from 2004 to 2013. Am J Trop Med Hyg. 2017;11:96(1).
Shaobai Zhang, Wenbiao Hu, Xin Qi, Guihua Zhuang. How socio-environmental factors are associated with Japanese encephalitis in Shaanxi, China — A Bayesian spatial analysis. Int. J. Environ. Res. Public Health. 2018;15:608.
Diaz J. Seasonal primary amebic meningoencephalitis (PAM) in the South: Summertime is PAM time. J La State Med Soc. 2012;164:148-150,152-155.