Asian Journal of Medical Principles and Clinical Practice <p style="text-align: justify;"><strong>Asian Journal of Medical Principles and Clinical Practice</strong>&nbsp;aims to publish high quality papers (<a href="/index.php/AJMPCP/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of Medical Science and Clinical Practice.&nbsp;AJMPCP will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. AJMPCP&nbsp;is novelty attracting, open minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results.&nbsp;This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> Asian Journal of Medical Principles and Clinical Practice en-US Asian Journal of Medical Principles and Clinical Practice Oral Administration of Ethanolic Leaf Extract of Vernonia amygdalina May Impact Negatively on Fertility in Male Wistar Rats <p><strong>Background:</strong> The use of <em>Vernonia amygdalina</em> leaves as vegetables and in folklore medicine for therapeutic activities is on the increase globally.</p> <p><strong>Aim:</strong> This study, therefore, sought to investigate the antifertility effect of <em>V. amygdalina</em> leaves in male Wistar rats.</p> <p><strong>Methods:</strong> Fresh and healthy leaves of <em>V. amygdalina</em> were harvested from the Institute of Agricultural Research and Training, Moor Plantation, Ibadan. They were dried and extracted using ethanol as the solvent. Thirty male Wistar rats were grouped into 6 of 5 rats each. Animals in groups A, B, and C were administered normal saline for 10, 20, and 30 days respectively via the oral route. Those in groups D, E, and F were treated with 500 mg/kg body weight of leaf extract of <em>V. amygdalina</em>. At the end of treatment, the animals were sacrificed by cervical dislocation. The internal organs were exposed. Testes and cauda epididymis were removed and kept in the sterilized glass. Male fertility parameters were determined using standard methods.</p> <p><strong>Results:</strong> Ethanolic leaf extract of <em>V. amygdalina </em>decreased sperm count and sperm motility while abnormality of spermatozoa increased significantly after 10, 20, and 30 days treatment respectively. However, seminal pH and sperm mortality were only perturbed after 30 days of treatment. The changes in seminal quality of <em>V. amygdalina </em>leaf treated-animals showed antifertility effects.</p> <p><strong>Conclusion:</strong> Excessive consumption of high doses of <em>V. amygdalina</em> may have a negative impact on sperm count, motility and viability of sperms, thus decreasing fertility. But this does not automatically translate to such effect on humans.</p> John A. Ekenjoku Augustine I. Airaodion Victor N. Okoroukwu Emmanuel O. Ogbuagu Uloaku Ogbuagu ##submission.copyrightStatement## 2019-10-16 2019-10-16 1 8 An Epidemiological Profile of Meningitis and Encephalitis in Adults Admitted to Benghazi Medical Centre in 2018 <p><strong>Objective: </strong>To describe epidemiological profile with respect to demographics and seasonal variations in occurrence of Meningitis, Encephalitis and Meningoencephalitis<em>.</em></p> <p><strong>Methods:</strong> A retrospective review of medical records of meningitis and Encephalitis and <em>Meningo-encephalitis</em> cases from 1<sup>st</sup> January 2018 to 31<sup>st</sup> December 2018 from Medicine department at Benghazi Medical Center in Benghazi city, Libya. All patients meeting the case definition were included .Data were collected using questionnaire on demographics including, age, sex, Address, and date of admission and date of discharge, diagnosis.</p> <p><strong>Results:</strong> From January to December 2018, 31 cases were identified, the mean age of all cases was (41.2) years. There were 20 (66.7%) of them males and 10 (33.3%) were females. The proportion of diagnosis of meningitis, encephalitis, and Meningoencephalitis was (22.6%), (25.8%), (51.6%) respectively. Differences were observed in the occurrence of each infection during the year seasons.</p> <p><strong>Conclusion: </strong>Based on data obtained, most infections occured in older age with gender differences in each type of infection. Seasonal variations noticed in all infections. This descriptive study was used as a screening tool to track cases and further larger epidemiological study is needed in order to plan effective preventive and surveillance measures.</p> Naeima Houseein Amenh B. Yousif Heba El-Zawawi Abdelhamid El-Zawawi ##submission.copyrightStatement## 2019-10-23 2019-10-23 1 7 Study the Protective Effects of Portulaca oleracea on Peptic Ulcer in Male Rats <p>Peptic ulcer disease is thought to result from a disturbed balance between the protective factors represented by the mucosa–bicarbonate barrier and the aggressive forces represented by acid and pepsin. This study aimed to investigate the effect of <em>Portulaca oleracea</em> juice on a peptic ulcer in rats. Twenty-eight male rats were divided into four groups of equal weight and number (5 rats each). Group I served as the positive control group (untreated group) and Group II served as a standard group (treated with the antiulcer agent), groups III and IV serviced as tested groups with <em>Portulaca oleracea </em>for two weeks at a dose of 0.50 and 1.00 ml/100 g of body weight, respectively. At the last day of the experimental period (14 days), all rats were starved of food but not of water for 18 hours. After fasting period, Groups I was given orally distilled water; standard group II was given (I/P) intra-perioteneally Zantac (ranitidine) at a dose 6 mg/100 g body weight, 60 min prior administered ethanol. Groups (I and II) were given orally saline and the other two groups were given<em> Portulaca oleracea </em>juice, 120 min prior administered ethanol. Then ethanol was administered orally to all `groups at 0.5 ml/100 g. After four hours of Ethyl alcohol administration, all animals were sacrificed and their stomachs were taken out and washed by normal saline. The gastric juice for each animal was collected to measure the volume of the gastric contents and pH value was measured. The present results showed that <em>Portulaca oleracea</em> extract had a significantly positive anti-ulcer effect which was more detectable with increasing doses of the extract. The present results concluded that regular intake of <em>Portulaca oleracea</em> had an anti-ulcer effect.</p> Alaa Qadhi Nehal A. A. Elfky ##submission.copyrightStatement## 2019-10-23 2019-10-23 1 8