Asian Journal of Medical Principles and Clinical Practice <p style="text-align: justify;"><strong>Asian Journal of Medical Principles and Clinical Practice</strong>&nbsp;aims to publish high quality papers (<a href="/index.php/AJMPCP/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of Medical Science and Clinical Practice.&nbsp;AJMPCP will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. AJMPCP&nbsp;is novelty attracting, open minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results.&nbsp;This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> Asian Journal of Medical Principles and Clinical Practice en-US Asian Journal of Medical Principles and Clinical Practice Origin Identification of Buckwheat from Different Areas in Loess Plateau by Chemical Analysis and Data Mining Techniques <p>In this study, the quality characteristics of mineral elements, vitamins and amino acids of 39 common buckwheat samples from the eastern, central and western regions of Loess Plateau were analyzed and compared and then effective indicators were selected for discrimination geographical origins. The linear discriminant analysis (LDA) was used to determine the geographical origin of common buckwheat according to three chemical families and their combinations each other. All models showed different correct classification rate and cross-validation rate. Among them, the correct classification rate and cross-validation rate of model based on the relative content of amino acid (the percentage of one amino acid in total amino acids) in combination with mineral elements were both 97.4%. The results demonstrated that the established method using multivariate analysis and data mining techniques was very effective and feasible for identification origin of buckwheat in the Loess Plateau.</p> Jing Yang Dong-Qin Wang Qiang Zhang Jian-Guo Xu ##submission.copyrightStatement## 2020-02-21 2020-02-21 1 10 Toxicological Evaluation and Anti-inflammatory Effects of the Anti-arthritic Herbal Formulations, Jointeez and Arthropower in Albino Wistar Rats <p><strong>Aim: </strong>This study investigated the toxicological and anti-inflammatory effects of some anti-arthritic herbal formulations.</p> <p><strong>Methodology: </strong>Forty-nine (49) female albino wistar rats grouped into seven groups of seven rats per group, were used for this study. Group A was the negative control while Group B was the positive control groups respectively. The rats in group B, C, D, E, F and G were induced with rheumatoid arthritis by injecting 0.1 ml of Complete Freund’s Adjuvant into their right hind paw. They were treated with the standard drug and herbal formulations respectively for 28 days as follows: Group C (treated with the standard orthodox drug, Celebrex), Group D (treated with the herbal drug, Jointeez), Group E (treated with a herbal drug, Arthropower), Group F (treated with a combination therapy of Jointeez and Celebrex) and Group G (treated with a combination therapy of Arthropower and Celebrex). The treatment was for 28 days, once daily. On the 29<sup>th</sup> day the rats were anaesthesized with chloroform and sacrificed through puncture of the jugular vein. Five milliliters (5 ml) of blood samples were put into plain bottles for the analysis of biochemical parameters and 3 ml into K<sub>3</sub>EDTA bottles for haematological analysis. The biochemical parameters were analysed using ELISA technique while haematological parameters were determined using Sysmex haematology autoanalyzer.</p> <p><strong>Results: </strong>The AST (p=0.006), ALT (p&lt;0.001) and ALP (p=0.001) were significantly reduced in the treated rats compared to the arthritic control group. TNF-α (p=0.001), IL-6 (p&lt;0.001), CRP (p=0.001) and WBC (p=0.001) were significantly reduced in the treated rats compared to the positive control group. Conversely, Haemoglobin (p&lt;0.001), Packed Cell Volume (p&lt;0.001) levels were significantly reduced in the positive control rats compared to the treated rats. The combination therapies used in this study did not offer significantly different therapeutic advantage over the monotherapies used. The herbal formulations gave therapeutic effects on the extra-articular effects similar to that obtained from the orthodox drug used in this study.</p> <p><strong>Conclusion: </strong>The herbal formulations can serve as safe regimens for rheumatoid arthritis in our population. It is recommended that herbal formulations be considered for integration into our healthcare system for the management of rheumatoid arthritis.</p> Kemzi N. Elechi-Amadi Holy Brown Ojoye N. Briggs Edna O. Nwachuku Boma H. Opusunju ##submission.copyrightStatement## 2020-03-14 2020-03-14 11 18 Attitude and Perceptions of Child Healthcare Practitioners in Nigeria to Autopsy Practice <p><strong>Introduction and Objectives:</strong> There has been a gradual decline in interest in postmortem audit worldwide despite the enormous potential value of the autopsies. In many paediatric centres across Nigeria, there is no policy providing the use of autopsy statistics in the main business of paediatric practice or as a means of assessing a centres’ performance. Even where such a policy exists, there is no compelling law for the incorporation of the statistics into daily paediatric practice. This study set out to survey the attitude and perception of child healthcare practitioners in Nigeria towards post-mortem examination in improving patients care.</p> <p><strong>Materials and </strong><strong>Methods:</strong> A cross-sectional descriptive study was done on participants attending a paediatric conference in Abuja, Nigeria. There were 250 respondents, who cut across the six geopolitical zones of Nigeria, consisting of paediatric consultants, residents and nurses. The study was done using self-administered questionnaires and data analysed using SPSS version 20.</p> <p><strong>Results:</strong> All (100%) participants believed autopsy practice was valuable and had a positive effect on medical practice. Sixteen (6.4%) respondents never request for autopsies, 120 (48.0%) respondents request for it rarely, 34 (13.6%) make a request often while 10 (4%) request for autopsies very often. Eighty-four (33.6%) respondents have never attended an autopsy session. The interval between autopsies and issuance of reports ranges from 0-3 weeks (48.0%) to &gt; 6 weeks (8.8%). The usual indications for requesting for autopsies include knowing the cause of death (85%), inability to arrive at a clinical diagnosis antemortem (71.2%) and improving clinical diagnosis skill and patient care (60.0%).</p> <p><strong>Conclusion: </strong>Autopsy practice is useful in paediatric practice but it is rarely requested for and infrequently attended by the child healthcare practitioner. There is a need to change the attitude and perception of all healthcare workers in paediatric practice through proper orientation and education.</p> C. Okechukwu ##submission.copyrightStatement## 2020-03-16 2020-03-16 19 25 The Quality of MCQs in Radiology Theory Lessons Assessed by the Millman Standard <p><strong>Background:</strong> One of the real concerns of society, especially students and teachers, in particular, is the issue of student assessment in content learning theory. If the assessment of these questions cannot asses students' knowledge, it discourages active students, and, on the other hand, less attention leads to having poor students, which has known implications, especially in dentistry that endangers the health of the community.</p> <p><strong>Aim:</strong> Therefore, this research was conducted to evaluate the radiological multiple-choice questions 1, 2 and 3 in the second semester of the academic year 2016-2017.</p> <p><strong>Methods:</strong> This study was a Cross-Sectional one and data were calculated by ANOVA and regression analysis.</p> <p><strong>Results:</strong> During the study, 278 students’ answers of 611 questions were evaluated in theoretical radiological lessons 1, 2 and 3. On radiology 1 out of 40 multiple choice questions and 102 students, discrimination indexes were 0.23 ± 0.15 and difficulty coefficient % 54.8 ± 92.43 and the correlation coefficient was 0.64 and on Radio 2 from the 36 multiple-choice question discrimination index was 0.81 ± 0.61, difficulty coefficient % 37.86 ± 21.69 and the correlation were 0.48. On Radio 3 out of 40 multiple-choice questions, the discrimination coefficient was 0.40 ± 0.02, correlation coefficient % 65.37 ± 17.89 and the correlation was 0.68. In examining ways of Millman. These principles were met in radiology 1 (% 96.75 ± 4.50) and in radiology 2 (% 95.65 ± 5.58) and in radiology 3 (% 29/50 ± 8/12).</p> <p><strong>Conclusion:</strong> It shows that radiology questions 1 and 2 were low discrimination index and difficulty coefficient Radio 1, 2 and 3 was average.</p> Nazanin Forghani ##submission.copyrightStatement## 2020-03-24 2020-03-24 26 34 Toxicological Effects of Overdose of Some Herbal Bitters Commonly Consumed in South Southern Nigeria <p><strong>Aim: </strong>The aim of this study was to evaluate the toxicological effects of overdose of Action Bitters and Goko Cleanser on hepatic, renal and haematological indices.</p> <p><strong>Methodology:</strong> Thirty-five (35) male albino wistar rats were divided into seven groups of five rats each. The six treatment groups were given the herbal extracts for four weeks while the control group was given distilled water. The study was carried in the Department of Medical Laboratory Science, Rivers State University, Port Harcourt, between June and August, 2019. Biochemical parameters were assayed using Mindray biochemistry analyzer while haematological parameters were assayed using Sysmex analyzer.</p> <p><strong>Results:</strong> There were significant increases in hepatic parameters (AST, ALT and ALP), renal parameters (Urea and Creatinine) and significant decreases in haematological indices (PCV and HB) in the treated groups, except for the normal dose weekly treatment group.</p> <p><strong>Conclusion:</strong> Long-term use or overdose of the herbal mixtures can lead to alterations in hepatic, renal and haematological indices.</p> Kemzi N. Elechi-Amadi Ojoye N. Briggs Boma H. Opusunju Nimisoere P. Batubo Ruth R. Ubulom Queen E. Solomon ##submission.copyrightStatement## 2020-03-25 2020-03-25 35 39