The Role of Immediate Fluid Resuscitation in Managing Patients of Sepsis in Critical Care Setting: A Literature Review

Amira Saleh Elmaghawry Elmoghazy *

Critical Care Medicine, Sheikh Shakhbout Medical City, United Arab Emirates.

*Author to whom correspondence should be addressed.


Abstract

Among the various critical care patients admitted to an ICU or CCU, several patients develop sepsis during their stay at the hospital. In another common scenario, it is also a very normal fact for patients to be brought to the hospital when they are suffering from sepsis. Sepsis is more common than it is thought of, and with no proper diagnosis or management done, it could compromise the patient's life. In many severe cases, the patient suffering from sepsis may also develop septic shock, which is even more lethal and could cause death sooner than expected in sepsis patients. Therefore, it is evident that these patients require the highest forms of care and management protocols, depending upon the severity of their situation.

However, in case all forms of treatment start failing and a poor prognosis becomes evident, then it is the need of time to intervene with resurrection measures and try their level best to help save the life of the patient. Resuscitation protocols are only seen to be effective when brought into action within the right time span. If it has already been too late, then there is little that could be done to help the patient.

This review focuses on the various resuscitation techniques that are followed amidst an emergency related to sepsis patients. The motive is to explore how effective these fluid resuscitation maneuvers are for improving the overall prognosis of the patient. It is already evident that whatever protocols or maneuvers would be followed, would be aggressive since the patient under consideration is already in a compromised state.

Keywords: Sepsis, septic shock, resuscitation, emergency, critical care, ICU settings


How to Cite

Elmoghazy , A. S. E. (2023). The Role of Immediate Fluid Resuscitation in Managing Patients of Sepsis in Critical Care Setting: A Literature Review. Asian Journal of Medical Principles and Clinical Practice, 6(2), 218–223. Retrieved from https://journalajmpcp.com/index.php/AJMPCP/article/view/180

Downloads

Download data is not yet available.

References

Lever A, Mackenzie I. Sepsis: Definition, epidemiology, and diagnosis. BMJ. Oct 27 2007; 335(7625):879–83.

Gyawali B, Ramakrishna K, Dhamoon AS. Sepsis: The evolution in definition, pathophysiology, and management. SAGE Open Med. Mar 21 2019;7:2050312119835043.

Basodan N, Al Mehmadi AE, Al Mehmadi AE, Aldawood SM, Hawsawi A, Fatini F, et al. Septic Shock: Management and Outcomes. Cureus. 2022 Dec 3;14(12): e32158.

Jarczak D, Kluge S, Nierhaus A. Sepsis—Pathophysiology and Therapeutic Concepts. Front Med. 2021 May 14;8: 628302.

Khan MI, Xu S, Ali MM, Ali R, Kazmi A, Akhtar N, et al. Assessment of multidrug resistance in bacterial isolates from urinary tract-infected patients. J Radiat Res Appl Sci. 2020 Jan 1;13(1):267–75.

Khan MI, Zahra Q ul A, Batool F, Kalsoom F, Gao S, Ali R, et al. Trends in Nanotechnology to improve therapeutic efficacy across special structures. OpenNano. 2022 Jul 1;7:100049.

Evans T. Diagnosis and management of sepsis. Clin Med. 2018 Apr;18(2):146–9.

Stearns-Kurosawa DJ, Osuchowski MF, Valentine C, Kurosawa S, Remick DG. The Pathogenesis of Sepsis. Annu Rev Pathol. 2011;6:19–48.

Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL. Sepsis and septic shock. Nat Rev Dis Primer. 2016 Jun 30;2:16045.

Wattanapaiboon K, Banditlerdruk S, Vattanavanit V. Presenting Symptoms in Sepsis: Is the Mnemonic “SEPSIS” Useful? Infect Drug Resist. 2020 Jul 8;13:2199–204.

Lever A, Mackenzie I. Sepsis: definition, epidemiology, and diagnosis. BMJ. 2007 Oct 27;335(7625):879–83.

Bullock B, Benham MD. Bacterial Sepsis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Aug 24]. Available:http://www.ncbi.nlm.nih.gov/books/NBK537054/

Mulatu HA, Bayisa T, Worku Y, Lazarus JJ, Woldeyes E, Bacha D, et al. Prevalence and outcome of sepsis and septic shock in intensive care units in Addis Ababa, Ethiopia: A prospective observational study. Afr J Emerg Med. 2021 Mar;11(1):188–95.

Lakbar I, Einav S, Lalevée N, Martin-Loeches I, Pastene B, Leone M. Interactions between Gender and Sepsis—Implications for the Future. Microorganisms. 2023 Mar 14;11(3):746.

Macdonald S. Fluid resuscitation in patients presenting with sepsis: Current Insights. Open Access Emerg Med OAEM. 2022 Nov 29;14:633–8.

Im Y, Kang D, Ko RE, Lee YJ, Lim SY, Park S, et al. Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study. Crit Care. 2022 Jan 13;26:19.

Rochwerg B, Oczkowski SJ, Siemieniuk RAC, Agoritsas T, Belley-Cote E, D’Aragon F, et al. Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis. Crit Care Med. 2018 Sep;46(9):1411–20.

Vincent JL, Abraham E, Annane D, Bernard G, Rivers E, Van den BergheG. Reducing mortality in sepsis: new directions. Crit Care. 2002;6(3):S1–18.

Leisman D, Wie B, Doerfler M, Bianculli A, Ward MF, Akerman M, et al. Association of Fluid Resuscitation Initiation Within 30 Minutes of Severe Sepsis and Septic Shock Recognition With Reduced Mortality and Length of Stay. Ann Emerg Med. 2016 Sep;68(3):298–311.

Byrne L, Obonyo NG, Diab SD, Dunster KR, Passmore MR, Boon AC, et al. Unintended consequences: Fluid resuscitation worsens shock in an ovine model of endotoxemia. Am J Respir Crit Care Med. 2018 Oct 15;198(8):1043–54.

Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial, Resuscitation JAMA, JAMA Network,Internet. cited 2023 Aug 24.

Available:https://jamanetwork.com/journals/jama/fullarticle/2654854

Semler MW, Rice TW. Sepsis Resuscitation: Fluid Choice and Dose. Clin Chest Med. 2016 Jun;37(2): 241–50.