An Assessment of Hepato-Protective Activity of Psidium guajava Fruit Extract against Hepatic Injured Rodent Model
Published: 2023-10-07
Page: 240-245
Issue: 2023 - Volume 6 [Issue 2]
Md. Abdullah Hil Baky Rupak
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
F. M. Sharifuzzaman Shohan
Department of Pharmacy, Primeasia University, Bangladesh.
Juliana Aditi Baroi
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Rahmat Ullah
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Mustafiz Chowdhury
Department of Pharmacy, University of Chittagong, Bangladesh.
Bornila Mehjabin
Department of Pharmacy, State University of Bangladesh, Bangladesh.
Puja Bhowmik
Department of Pharmacy, University of Science & Technology Chittagong, Bangladesh.
Nur-Neasha Dolon
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
Rafat Tashin *
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Herbal remedies are the art or practice of using herbs and herbal medicines to maintain health and prevent, treat, or cure sickness. The lipid profiles of Psidium guajava extract were studied in rats. In the case of Serum glutamic pyruvic transaminase (SGPT) and serum glutamic-oxaloacetic transaminase (SGOT), only the high dose produced statistically significant (p<0.05) outcomes as compared to the negative control group. At low, medium, and high dosages, creatinine levels decreased statistically significant (p<0.05). However, none of the dosages in case of urea produced statistically significant (p<0.05) effects. Only at high dosages did total cholesterol levels reduce statistically significantly (p<0.05) when compared to the negative control group. Only at high doses did High Density Lipoprotein (HDL) levels improve statistically significantly (p<0.05). High and medium dosages of Low Density Lipoprotein (LDL) significantly (p<0.05) reduce the quantity in the blood. Triglyceride levels were reduced only at high dosages as compared to the negative control group. These discoveries may benefit those suffering from liver disorder.
Keywords: Psidium guajava, SGPT, Herbal medicine, phytopharmacology, cholesterol