An Assessment of Hepatoprotective Activity of Citrullus Lanatus in CCL4-Induced Hepatotoxicity in Rats with Safety Profile Analysis
Published: 2023-10-09
Page: 246-252
Issue: 2023 - Volume 6 [Issue 2]
Masruk Alam
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Tasnimur Rahman Khan
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Kazi Sakib
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Misuk Chandra Ray
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Souvik Kumar Mandal
Department of Pharmacy, Gono Bishwabidyalay, Mirzanagor, Savar, Dhaka, Bangladesh.
Tasnia Rahman
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Tamanna Shahrin Tonny
School of Pharmacy, BRAC University, Dhaka, Bangladesh.
Sara Rahmat
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Amrin Yeasin Proma
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Rafat Tashin *
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
Humans have been discovering and incorporating medicinal plants, also known as medicinal herbs, into conventional medical processes since the beginning of time. The researchers investigated the effect of Citrullus lanatus extract on lipid profiles in rats. Throughout the treatment period, rats were given CCl4 and treatment species once a day. Both medium and high doses of the plant extract showed statistically significant (p < 0.05) changes in Serum Glutamic Pyruvic Transaminase (SGPT) and serum glutamic-oxaloacetic transaminase (SGOT) compared to the positive control group. Creatinine levels showed a statistically significant reduction (p < 0.05) at low, medium, and high doses. However, at high doses, urea demonstrated a statistically significant effect (p < 0.05).
Keywords: Citrullus lanatus, medicinal plant, creatinine, statistical significance, high dose