The Chest Radiographic Findings and the Viral Load in Adult Patients with HIV/PTB Co-Infection
Published: 2024-05-23
Page: 268-278
Issue: 2024 - Volume 7 [Issue 1]
Uzukwu Ifeanyi Olisa
Department of Radiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Nwosu, Chinekwu Skye *
Department of Radiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Nwabunike Munachi Onyebuchi
Department of Radiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Isiakpu Idorenyin Okon
Department of Radiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Obi-Nwosu Amaka Lovelyn
Department of Family Medicine Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Introduction: The human immunodeficiency virus (HIV) infection continues to modify the radiographic pattern of pulmonary tuberculosis (PTB). There is an increase in the prevalence and transmission of multidrug-resistant and drug-resistant MTB strains worldwide.
Aim: To determine the relationship between the chest radiographic findings of patients with HIV/PTB co-infection and the viral load.
Methods: This is a prospective study of 112 HIV/PTB co-infected subjects using chest radiographs at full inspiration and the viral load.
Results: There were 112 Nigerian subjects with HIV/PTB co-infection, of which 79 (70.5%) had viral load > 10,000 copies/ml, 41(36.6%) were females, and 38(33.9%) were males. Plasma viral load of 20-10,000 copies/ml showed 28(25%) male subjects and 14 (12.5%) female subjects. While viral load of < 20copies/ml showed females 4(3.5%) and males 1(0.9%). For normal radiographs, 13(11%) subjects with viral load > 10,000 copies/ml were seen while none were seen in subjects with < 20 copies/ml with a p-value = 0.459. Opacities were seen in 60 (53.6%) of subjects with viral load > 10,000 copies/ml and 4 (3.6%) of subjects with viral load < 20 copies/ml with a p-value= 0.670. There was no significant relationship between the zonal distribution of opacities and the chest radiographic findings with the subjects’ viral load categories.
Conclusion: The chest radiographic findings did not show any significant differences in appearance in the different viral load categories of the subjects.
Keywords: Viral load, copies/ml, subjects, HIV, PTB
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References
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