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Scientifically called Coffea Arabica, Research interests in Coffee have expanded with the discovery of its antioxidant properties. Coffee is a popular beverage consumed worldwide. Its effect on health has been a global puzzle. In this study, the effect that coffee consumption has on Oxidative stress parameters (Superoxide dismutase, Glutathione peroxidase, Catalase and Malondialdehyde) was examined. A hundred (100) Wistar rats bred in the Animal house of the Faculty of Basic Medical Science of Delta State University were used for the Study. While thirty (30) of them were used for toxicity test, Seventy (70) rats were randomly selected into groups of ten (10) rats with seven (7) groups each. All animals were fed with normal rat chow and water. All the experimental rats were treated for four (4) weeks period. Group 1, control, received food and water only, groups 2, 3 and 4 received 40 mg/kg, 60 mg/kg and 80 mg/kg, doses of Coffee respectively while Groups 5, 6 and 7 received 30 mg/kg, 45 mg/kg and 60 mg/kg doses of Caffeine respectively. After administrations of test substances, animals were sacrificed accordingly and serum samples collected for analysis of oxidative stress parameters. Both Caffeine and Coffee treatments showed a dose-dependent effect on most parameters measured. Coffee was found to greatly increase antioxidant enzymes. All comparisons were done at (P<0.05).