Advanced Treatment of Type 1 Diabetes with Teplizumab: Mechanism and Clinical Efficacy
Tejas Chavan *
Rashtriya College of Pharmacy, Hatnoor, Kannad, Sambhaji Nagar, Maharashtra, India.
Suresh Waghamare
Rashtriya College of Pharmacy, Hatnoor, Kannad, Sambhaji Nagar, Maharashtra, India.
Shubham Kokare
Rashtriya College of Pharmacy, Hatnoor, Kannad, Sambhaji Nagar, Maharashtra, India.
Aniruddha Madake
Rashtriya College of Pharmacy, Hatnoor, Kannad, Sambhaji Nagar, Maharashtra, India.
*Author to whom correspondence should be addressed.
Abstract
Teplizumab, a humanized anti-CD3 monoclonal antibody, has emerged as a significant advancement in the treatment of type 1 diabetes (T1D), an autoimmune disease characterized by the destruction of insulin-producing pancreatic beta cells. As the first FDA-approved disease-modifying drug for T1D, teplizumab has demonstrated efficacy in delaying the onset of stage 3 T1D in adults and pediatric patients 8 years and older with stage 2 T1D. Clinical trials have shown that teplizumab can preserve beta cell function, reduce insulin requirements, and improve glycemic control in newly diagnosed T1D patients. The drug's mechanism of action involves modulating the immune response responsible for beta cell destruction by altering the function of T-lymphocytes, inducing regulatory T cells, and promoting the accumulation of exhausted-like CD8 T cells. Teplizumab's efficacy appears to be influenced by factors such as the microbiome and the induction of partially exhausted CD8 T cells, which exhibit reduced secretion of inflammatory cytokines. While teplizumab has shown promise in preserving beta cell function and delaying T1D onset, challenges remain in optimizing treatment protocols and addressing potential side effects, including lymphopenia and skin disorders. Future research directions include exploring combination therapies, identifying predictive biomarkers, and refining patient selection to maximize treatment outcomes. Teplizumab's success in T1D has implications for the broader field of immunotherapy in autoimmune diseases, demonstrating the potential of targeted immunomodulation in altering disease.
Keywords: Teplizumab, type 1 diabetes, autoimmune disease, beta cells, FDA-approved, disease-modifying drug, delayed onset, preserved beta cell function, modulating immune response, immunotherapy