Histo-architectural and Renal Function Markers in Long Term Consumption of Instant Noodles in Adult Wistar Rats

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Adjene Josiah Obaghwarhievwo
Garba Abdullahi
Odigie Mike Osagie


This study investigated the morphological and biochemical changes in the kidney of adult wistar rats fed with instant noodles. Fifty (50) adult wistar rats of an average of 180g were procured for the study. After two weeks of acclimatization, the rats were randomly grouped into five (5) (A, B, C, D and E) of ten (10) rats per group. Group A animals were fed with cooked instant noodle (Type A), group B rats received cooked instant noodles with its spice, group C received cooked noodle (type B) only, and group D animals received cooked instant noodles (type B) with its spice while group E (control animals received grower marsh for thirty (30) days. At the end of the administration of test substances, the animals were sacrifice by cervical dislocation and kidney tissue harvested and subjected to histological technique. Assay of selected renal function markers [Urea and Creatinine levels] was also conducted using serum. Statistical Package for Social Sciences (SPSS version 21) was used to evaluate the data obtained. Results (H&E) revealed that there was an enlarge Bowman’s space distortion and disruption  of  the cyto-architecture of  the renal cortical structure and marked sign of diffuse nephritis  of treated animals as compared to the control animal but with that  of  treated group B more marked. Study also found a statistically significant increase in             serum urea levels of groups B, C and D wistar rats as compared to control; whilst observing a significant increase in serum creatinine levels of groups A and D wistar rats only as against the control (group E). Further study aimed at corroborating the findings from this work should be encouraged.

Kidney, instant noodles, histo-architecture, renal function markers.

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Josiah Obaghwarhievwo, A., Abdullahi, G., & Mike Osagie, O. (2020). Histo-architectural and Renal Function Markers in Long Term Consumption of Instant Noodles in Adult Wistar Rats. Asian Journal of Medical Principles and Clinical Practice, 2(3), 1-9. Retrieved from http://journalajmpcp.com/index.php/AJMPCP/article/view/30105
Original Research Article


Maton A, Jean H, Charles W, Malaughlin Susan J, Maryanna WW, David L, Jill DW. Human Biology and Health Englewood Cliffs, New Jersey, USA: Prentice Hall; 2013.
[ISBN: 0-13-981176-1]

Tolaram Group. Instant noodles industry in Nigeria and related issues; 2012.
Available:www.lbs.edu.ng/LBSBreakfastClub/ Nigeria%20Noodle%20Industry.pdf
(Accessed 04 October 2017).

Udeogu E, Onyeka EU, Umelo MC. Potentials of using cowpea - wheat composite flour in noodles products. European international Journal of Applied Science and Technology. 2014;1.

Marketing Edge. Battle of noodles brands over market share; 2017.
(Accessed 04 October 2017)

World Instant Noodles Association. Global demand of instant noodles: Top 15; 2016.

Sanni M, Ejembi D, Emmanuel TF, Abbah OC, Okwutachi SO. Effects of chronic administration of indomie noodles on the activity of alkaline phospatase of rat small intestine. Journal of Pharmaceutical and Biomedical Sciences. 2013;34(34):1682-1687.

Morgan M, Keeffe EB. Diagnosis and treatment of chronic hepatitis B. update. Minerva Gastroenterol.Dietol. 2009(1);55: 5–22.

Sikander M, Arif M, Muhammad S, Ghayas K, Qurratal-Ain M, Rabia GK. Instant noodles: are they really good for health? Electronic Journal of Biology. 2017;(3): 222–227.

Eze GI, Ehimugbai ARO, Ezugwu WS, Okafor FO. Morphological changes-induces by instant noodles food on kidney of adult New Zealand Rabbit. IOSR Journal of Dental and Medical Sciences (IOSR–IDMS). 2017;16(1).
[e–ISSN: 2279–0858]
[ISBN: 2279 – 0861]

Adi AH, Alturkmani HJ. Physiologically lucky: The role of medical physiology in modern medical education: an inter¬view. Perspect Med. Educ. 2013;2:99–103.

Kim HK, Ahn Y. Mortality trends of cardiovascular disease in Korea; big challenges in ischemic heart disease. Korean Circ J. 2015;45:192-3.

Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH, Jr, et al. Screening for renal failure: A Comparison of Currently Available Diagnostic Tests. 2008;48(4):1167–74.

Kim MJ, Shin SN, Kim SK. Proximate composition and calorie of Korean instant noodles. Korean J Food Sci. Technol. 2000;32:1043-50.

Misra H, Fridovich I. The purification and properties of superoxide dismutase from Neurospora crassa. J. Bacteriol. 1972; 247:3410.

Enaibe BU, Adjene JO, Eweka AO, Adefolaju GA. Histological effects of camphor administration on the histology of the Kidney of Rabbit (Oryctolagus cuniculus). Centre point (Science edition). 2007;14(1&2):118-124.

Jarup L. Hazards of heavy metal contamination. Br Med Bull. 2003; 68(1):167–182.

Shin HJ, Cho E, Lee HJ, Fung TT, Rimm E, Rosner B, Manson JE, Wheelan K, Hu FB. Instant noodle intake and dietary patterns are associated with distinct cardiometabolic risk factors in Korea. J Nutr. 2014;144:1247-55.

Lee ET. Utilization of Austrailian wheat for Korean style dried noodle making. J. Cereal Sci. 2009;6:283–297.

Ahsan R, Islam M, Bulbul JI, Musaddik A, Haque E. Hepato¬protective activity of methanol extract of some medicinal plants against carbon tetrachloride-induced hepatotoxicity in rats. Eur. J. Sci. Res. 2009;37:302–310.

Adjene JO, Ezeoke JC, Nwose EU. Histological effects of chronic consumption of soda pop drinks on kidney of adult wistar rats. North Am J Med Sci. 2010; 2(5):215-217.

Al-Busaidi M, Yesudhason P, Al-Mughairi S, Al-Rahbi WA, Al-Harthy KS, Al-Mazrooei NA, Al-Habsi SH. Toxic metals in commercial marine fish in Oman with reference to national and international standards. Chemosphere. 2011;85(1):67–73.

Das AK. Environmental chemistry with green chemistry. Arvinaba Sen Books and Allied (p) ltd, Kolkata. 2010; 201.

Adjene JO, Nwose EU. Histological effects of chronic administration of phyllanthus amaranthus on the kidney of adult wistar rats. North Am J Med Sci. 2010;2(4):193-195.