Effect of Morinda Lucida Leaf Extract on Ibuprofen Induced Nephrotoxicity Albino Rats
Asian Journal of Medical Principles and Clinical Practice,
Morinda lucida ethanol stem bark extract dilution of ((500, 1000, 1500) mg /kg) body weight were administered to B1, B2, B3 groups subjected to ibuprofen induced nephrotoxicity. Histomorphological studies on target organ; kidney were harvested, weighed and processed. Ibuprofen toxic activities of the extracts treated groups (serum biochemical markers) and the relative organ index (ρ<0.05) in treated groups respectively produce significant changes. Target organ extract examinations offered some protection on glomerular and tubular degenerative changes while there are deterioration changes in B groups.
- albino rats
How to Cite
Adejo GO, Atawodi SE. Acute Toxicity and Genotoxic Effects of all Parts of Morinda lucida Benth on pUC18 Plasmid DNA. Natural Products Chemistry Research. 2014;S1. DOI: 10.4172/2329-6836.S1-006.
Adeneye AA. Profile of Morinda lucida Leaf Fractions on Blood Glucose and Lipids in Normal and Alloxan-Induced Hyperglycaemic Rats. Journal of Pharmacology. 2013;4(5):408-413.
Adeneye AA, Olagunju JA, Olatunji BH, Balogun AF, Akinyele BS, Ayodele MO. Modulatory Effect of Morinda lucida Aqueous Stem Bark Extract on Blood Glucose and Lipid Profile in Alloxan-Induced Diabetic Rats African Journal Biomedical Research. 2017;20:75- 84.
Laguipo, Angela. Anatomy of the Kidney. News-Medical; 2018.
Retrieved on March 03, 2021 Online: https://www.news-medical.net/health/Anatomy-of-the-Kidney.aspx
Dalal R, Bruss ZS, Sehdev JS. Physiology, Renal Blood Flow and Filtration In; 2021. Available:https://www.ncbi.nlm.nih.gov/books/NBK482248/.
Pizzorno J. The Kidney Dysfunction Epidemic, Part 1: Causes. Integrative Medicine (Encinitas, California). 2015; 14(6):8–13.
Patel JB, Sapra A. Nephrotoxic Medications. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021. [Updated 2021 Feb 23]. Available:https://www.ncbi.nlm.nih.gov/books/NBK553144/
Baisakh Pratima, Mohanty Biswa, Agrawal Divya, Baisakh MR, Dulta BK, Chinara PK. Effect of Ibuprofen on Kidney of Albino Rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014;5(5):136-142.
Abbas Mohammed Talat, Abed Rabab Murtadha and Metab Nazar Jabar. The Effect of Olive Oil on Ibuprofen Induced Renal Toxicity in Female Rats. Kerbala Journal of Pharmaceutical Sciences. 2017;(13):167-177.
Sabatino David, Tillman Michael, Pawasauskas Jayne and Todd Brothers. Nonsteroidal Anti-Inflammatory Drug Induced Acute Kidney Injury; A Review and Case Study. Journal of Renal Injury Prevention. 2020;9(4):e34.
GuilhermeNobre Cavalcanti Lucas, Ana Carla Carneiro Leitão, Renan Lima Alencar, Rosa Malena Fagundes Xavier, Elizabeth De Francesco Daher and Geraldo Bezerra da Silva, Junior. Pathophysiological Aspects of Nephropathy Caused by Non-Steroidal Anti-Inflammatory Drugs. Brazillian Journal of Nephrology. 2019;41(1):124–130.
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