The Effect of Being Vaccinated on Respiratory Mechanics and Mortality in Critically Ill Patients with COVID-19
Asian Journal of Medical Principles and Clinical Practice,
Page 1-6
Abstract
Background: The Coronavirus disease 2019 (COVID-19) is a disease that affects the human population globally and often causes the death of hundreds of thousands of people with lung involvement. In recent years, it is an unprecedented reason for occupancy in hospital wards and intensive care units.
Aims: In this study, it was aimed to compare the lung dynamics, prognosis, and mortality of vaccinated and unvaccinated patients in the intensive care unit.
Study Design: Patients hospitalized in Intensive Care Units between August 1, 2021 and September 30, 2021 were retrospectively examined.
Methods and Materials: A total of 197 vaccinated and unvaccinated patients over 18 years of age, with positive Polymerase Chain Reaction (PCR) tests, and hospitalized in the intensive care unit were included in the study. Age, gender, comorbidity, vaccination, oxygen support, mechanical ventilator parameters, intubation times, radiology data and mortality of the patients included in the study were examined.
Results: This study, COVID-19 disease is more common in male gender, patients over 65 years of age and those with comorbidities. Unvaccinated patients are 4 times more likely vaccinated patients to be in intensive care. Almost all patients need oxygen support, but intubation is more often in unvaccinated patients. Mortality rates in the intensive care unit; it was found in 18% vaccinated patients, 64% unvaccinated patients, 53.8% overall. The most common causes of mortality were Acute Respiratory Distress Syndrome (ARDS) and sepsis.
Conclusion: Severe ARDS is more often to unvaccinated patients. Lung dynamic compliance <18 mL/cmH2O is related with mortality. Severe lung damage on Computed Tomography (CT) score is related with ARDS and mortality. Mortality is more often to unvaccinated patients.
Keywords:
- COVID-19
- critically
- respiratory
- unvaccinated
- vaccinated
How to Cite
References
Published Online Jan 27, 2022.
Bhatraju PK, Ghassemieh BJ, Nichols M, et al. COVİD-19 in Critically Ill Patients in the Seattle Region — Case Series. New England Journal of Medicine; 2020.
Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA; 2020.
Saeed GA, Gaba W, Shah A, et al. Correlation between chest CT severity scores and the clinical parameters of adult patients with COVID-19 pneumonia. Hindawi Radiology Research and Practice. 2021;1-7.
Ligong L, Hui Z, Meixiao Z, et al. Antibody response and therapy in COVID-19 patients: What can be learned for vaccine development. China Life Sci. 2020;63(12):1833-1849.
Michael H, Alice H, Yovita T. COVID-19 vaccination efficacy and safety literature review. J Clin Med Res. 2021;3(1):1-10
Camporota L, Vasques F, Sanderson B, et al. Identification of pathophysiological patterns for triage and respiratory support in COVID-19. Lancet Respir Med. 2020;8(8):752–4.
Diehl JL, Peron N, Chocron R, et al. Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study. Ann Intensive Care. 2020;10(1):95.
Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med; 2020.
Available:10.1001/jamainternmed.2020.0994
Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID‐19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8:420–422.8.
Tian S, Xiong Y, Liu H, et al. Pathological study of the 2019 novel coronavirus disease (COVID‐19) through postmortem core biopsies. Mod Pathol; 2020.
Available:10.1038/s41379-020-0536-x
Ye Z, Zhang Y, Wang Y, et al. Chest CT manifestations of new coronavirus disease 2019 (COVID‐19): a pictorial review. Eur Radiol; 2020.
Available:10.1007/s00330-020-6801-0
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395:1054–62.
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395:497–506.
Puah SH, Cove ME, Phua J, et al. Association between lung compliance phenotypes and mortality in COVID-19 patients with acute respiratory distress syndrome. Ann Acad Med Singap. 2021; 50(9):686-694.
-
Abstract View: 33 times
PDF Download: 10 times
