Asian Journal of Medical Principles and Clinical Practice 2021-04-16T06:51:39+00:00 Asian Journal of Medical Principles and Clinical Practice Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Medical Principles and Clinical Practice</strong>&nbsp;aims to publish high quality papers (<a href="/index.php/AJMPCP/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of Medical Science and Clinical Practice.&nbsp;AJMPCP will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. AJMPCP&nbsp;is novelty attracting, open minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results.&nbsp;This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> Mean Arterial Pressure 65 mmHg as A Cut-Off Point for Successful Non-Operative Management of AAST Grade III Liver Injury Associated with Stable Hemodynamic on Blunt Abdominal Trauma Patients (A Serial Case Report) 2021-04-16T06:51:39+00:00 Donny Artya Kesuma Ida Bagus Budhi <p><strong>Aims: </strong>To report 2 cases of blunt abdominal trauma with AAST Grade III liver injury and the mean arterial pressure as a cut-off point for successful non-operative management of AAST Grade III liver injury associated with stable hemodynamic.</p> <p><strong>Case Description: </strong>2 cases of blunt abdominal trauma with AAST Grade III liver injury treated in Dr. Moewardi General Hospital Surakarta. The patients performed with stable hemodynamic. The patients were treated conservatively (non-operative). They got resuscitation and their vital signs were monitored strictly. The Mean Arterial Pressure was maintained in 65 mmHg with fluid resuscitation and blood transfusion.</p> <p><strong>Discussion: </strong>The decision to manage operatively or conservatively was made by evaluating hemodynamic state, not from the result of CT scan. CT scan can be useful for predicting the result of conservative treatment. Mean Arterial Pressure ≥ 65 mmHg can secure the macrocirculation functioning well. Prolonged arterial hypotension can make hypovolemic shock irreversible and increase mortality. In the other side, permissive hypotension during the acute phase of trauma is needed as a part of <em>Damage Control Resuscitation</em> to achieve hemostatic condition as soon as possible. We should keep cautious when we choose non-operative management, especially monitor the late complications such as delayed bleeding, DIC, sepsis and the sign of peritonitis that can be the indications to surgery.</p> <p><strong>Conclusions:</strong> The recommended initial target MAP for successful non-operative management of AAST Grade III liver injury associated with stable hemodynamic on blunt abdominal trauma patients is 65 mmHg to avoid prolonged arterial hypotension that can lead to irreversible shock and increase mortality.</p> 2021-04-16T00:00:00+00:00 ##submission.copyrightStatement## Changes in GFAP Levels between Pre and Post Ventriculoperitoneal Shunts in Hydrocephalus Patients 2021-04-13T11:39:48+00:00 Ricky Masyudha Untung Alifianto Ferry Wijanarko Hari Wujoso <p><strong>Introduction: </strong>Hydrocephalus is a disease that attacks the brain. Glial fibrillary acidic protein (GFAP) is a structural cytoskeleton protein expressed by astroglial and neuronal stem cells. One of the hydrocephalus treatments is the VP Shunt. After the treatment through the VP Shunt procedure, GFAP levels generally change. This study aims to determine changes in serum GFAP levels before and after insertion surgery VP Shunt in hydrocephalus patients.</p> <p><strong>Methodology: </strong>This study was an analytic observational quantitative study with a cross-sectional approach. The research subjects were patients with hydrocephalus who were treated at the Neurosurgery Section of the Regional General Hospital Dr. Moewardi from April to June 2020.</p> <p><strong>Results and Discussion: </strong>This study had 14 subjects consisting of 9 (64.3%) male subjects and 5 (35.7%) female subjects. The median value of GFAP levels before treatment was 370.5 pg/mL with the lowest level of 168 pg/mL and the highest of 1734 pg/mL. The median value of GFAP levels after VP shunt action was 249.5 pg/mL with the lowest value of 137 pg/mL and the highest of 724 pg/mL. It was found that the GFAP level before and after the VP shunt action had a significant difference with p = 0.035 (p &lt; 0.05).</p> <p><strong>Conclusion: </strong>There is a significant difference between the GFAP serum levels before the action and after VP Shunt was performed in hydrocephalus patients.</p> 2021-04-13T00:00:00+00:00 ##submission.copyrightStatement## Clinic - Diagnostic Aspects of Modern Biomarkers of Early Atherosclerosis and Fibrotic activity of Systemic Scleroderma 2021-04-13T11:29:47+00:00 Ganiyeva Nafisa Abrarovna Rizamukhamedova Mashkhura Zakirovna Nabiyeva Dildora Abdumalikovna Aripova Nozima Abrarovna <p>Systemic sclerosis (SS) is a systemic disease with heterogeneous clinical manifestations of the skin and internal organs. It is believed that the triggering mechanism of its development is initial vascular damage, which leads to inflammatory reactions and the development of the accumulation of collagen and other components of the extracellular matrix. It goes without saying what a disease treatment is. Diagnosis of SS is carried out by clinical observation and using methods such as the Rodnan skin counter (mRSS), durometry, cutometry, and ultrasound determination of skin thickness. These methods are quite of thickness of intima complex (TIC) consuming and subjective. In addition, these methods do not provide information about the activity of the fibrotic process. These disadvantages of the listed methods can be compensated for by studying biomarkers that reflect the activity of inflammatory and fibrotic processes, but can be used to assess the prognosis and effectiveness of treatment. The aim of the review focuses on cardiac and fibrotic biomarkers of patients with scleroderma. These include growth factors, cytokines and proteases, their inhibitors, as well as proteins of the extracellular matrix, especially collagens, adapted to skin biopsies and in serum samples from patients with SS. Summarized information on non-invasive physical and laboratory studies is proposed, which provides a better understanding of cardiovascular disease and fibrotic activity, can be effectively used to assess the potential therapeutic response and help in choosing the opTICal treatment options for SS.</p> 2021-04-13T00:00:00+00:00 ##submission.copyrightStatement##