Asian Journal of Medical Principles and Clinical Practice <p style="text-align: justify;"><strong>Asian Journal of Medical Principles and Clinical Practice</strong>&nbsp;aims to publish high quality papers (<a href="/index.php/AJMPCP/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of Medical Science and Clinical Practice.&nbsp;AJMPCP will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. AJMPCP&nbsp;is novelty attracting, open minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results.&nbsp;This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> Asian Journal of Medical Principles and Clinical Practice en-US Asian Journal of Medical Principles and Clinical Practice Comparative effects of Carica Papaya, Avocado Pear and Ginger Extracts on the Histological Structure of the Pancreas of Streptozotocin-induced Diabetic Rats <p><strong>Introduction: </strong>The increasing global prevalence of diabetes mellitus requires a holistic approach for its management. This study was carried out to compare the effects of <em>Carica papaya </em>(Pawpaw) leaves, <em>Persea americana</em> (Avocado pear) and <em>Zingiber officinale</em> (Ginger) on the histological structure of the pancreas of Streptozotocin (STZ)-induced diabetic wistar rats.</p> <p><strong>Methodology:</strong> Fifty (50) male wistar rats with weights ranging from 170-250g were used for this study. They were divided into five groups (I, II, III, IV, and V) of 10 rats each. Groups II, III, IV and V were given 50 mg/kg STZ freshly dissolved in 0.1M citrate buffer (P<sup>H</sup> 4.5) in a volume of 1ml/kg body weight intraperitoneally to induce diabetes mellitus while Group A served as non-diabetic controls while Group B served positive controls. Group C, D, and E were given 3g/100ml body weight of freshly prepared of aqueous extract of <em>Carica papaya</em> leaves, Avocado Pear and Ginger respectively. The treatment continued for 28 days, then rats were anesthetized, and their pancreas were extirpated and processed for light microscopic examinations. The blood glucose levels were determined, and the weights were also taken at baseline and during the treatment.&nbsp;</p> <p><strong>Results:</strong> The STZ-induced rats exhibited hyperglycemia accompanied with increases in glucose and loss in body weight. Aqueous extract of <em>Carica papaya </em>leaves, Avocado Pear and Ginger were found effective in lowering serum glucose and returned the weight of treated diabetic rats to almost original values. Microscopic examination of the pancreatic sections of diabetic rats treated with aqueous extract of <em>Carica papaya</em> leaves, Avocado Pear and Ginger revealed regeneration of islet of langerhans compared with the untreated diabetic group. Although the three plants have regenerative abilities on islets of Langerhans, <em>Carica papaya</em> has more regenerative potentials than the other two plants.&nbsp;</p> <p><strong>Conclusion:</strong> Results from this study showed that treatment with aqueous extracts from <em>Carica papaya</em>, Avocado Pear, and Ginger were effective in lowering hyperglycemia Spreptozotocin-induced&nbsp; diabetic Wistar rats.&nbsp;</p> <p><strong>Recommendation: </strong>The herbal plants used for this study should be used as candidate substances for the development of regimens for the management and treatment of diabetes mellitus.</p> Joseph Ozegbe Ebifa H. M. D. Kemzi Elechi-Amadi H. M. D. Chiamaka Abiakam Ojoye N. Briggs ##submission.copyrightStatement## 2021-06-23 2021-06-23 1 11 Isolation, Molecular Identification and Plasmid Profiling of Staphylococcus Species from Nasal Carriage of University Some Students of Rivers State University, Port Harcourt, Nigeria <p>Nasal carriage with <em>Staphylococcus</em> species is a common risk factor for invasive infections, indicating the necessity to monitor prevalent strains, This study was aimed to isolation, molecularly identify, and profile the plasmid of <em>Staphylococcus</em> species from the nasal carriage of some University students of Rivers State University, Port Harcourt, Nigeria. Fifty (50) Nasal swab samples were collected from the anterior nares of some students of Rivers State University using sterile cotton swabs. The samples were examined for the presence of <em>Staphylococcus </em>species using standard bacteriological methods by streaking on mannitol salt agar and incubated for 24 hours at 37.2⁰C.&nbsp; Identification and plasmid proofing of the isolated <em>Staphylococcus</em> species were carried out using genomics studies. The results showed that 48 out of the 50 samples examined were positive <em>Staphylococcus</em> species which includes <em>Staphylococcus aureus, Staphylococcus gallinarum</em>,<em> Staphylococcus simulans </em>, <em>Staphylococcus sciuri, </em>and<em> Staphylococcus Camosus, </em>this indication that <em>Staphylococcus </em>species does not only colonize sick or individuals with the sign of infection but also healthy individual, The results of plasmid profiling of the five <em>Staphylococcus</em> species revealed that all the species posses plasmid which is capable to enhance their resistance to the commonly used antibiotics The presence of these <em>Staphylococcus</em> species is a serious public concern because even though only <em>S. aureus</em> is the only known human pathogen others could be opportunistic pathogens. Therefore continuous surveillance and improvement of personal hygiene standards among students is highly recommended such as hand washing with soap and warm water since <em>Staphylococcus </em>species can quickly be spread among students.</p> U. Oparaodu N. N. Odu G. A. Uzah ##submission.copyrightStatement## 2021-07-21 2021-07-21 12 20